Prevalence of Helicobacter Pyloriin Children with Type 1 Diabetes Mellitus and its Association with C-peptide and HbA1c

Helicobacter Pyloricauses gastrointestinal tract infection as well as Extra-gastric disorders with increased infection rates in developing countries. It was recently observed that these bacteria may increase their prevalence in patients with diabetes mellitus type 2.

Therefore, the present study aimed to find out the prevalence H. pylori in DMT1 in children, and its association with C-peptide and HbA1c.

A total of (204) samples 91 male (44.6%)and 113 female (55.4%) were collected form type 1 diabetic children with age range (1–15) years from the Specialist Center for Endocrinology and Diabetes, Ibn Al-Baladi Hospital for Children and Women. Ethical consent and case history were obtained from parents according predesigned questionnaire. Chromatographic immunoassay rapid test was used to detect H. pylori infection seropositivity and the immunoassay analyzer cobas e411 was used for HbA1c and C-peptide.

H. pylori seropositivity 61(30%) cases out from total 204 type 1 diabetic case. The C-peptide results showed significant differences between H. pylori positive and negative groups (p=0.023). Significant differences were found among the H. pylori positive, negative type 1 diabetic cases and apparently healthy in both HbA1c and C-peptide (p ≤0.001).in addition, significant positive relationship between the H. pylori infection and C-peptide (Pearson correlation= 0.663 p≤0.001).

This study concluded that there is association between H. pylori infection and C-peptide in type 1diabetic children.