Proinlammation and Anti Inflammation in Contrast Induced Nephrophaty Patient after Administration of Contras Media; Analysis of Interleukin 18 and Interleukin 37 Levels

Contrast induced nephrophaty is potential side effect of contrast administration. A good marker is required in order to synergize with the creatinine marker so that CIN can be handled more quickly. This study aimed to compare the levels of interleukin 18 as a marker of inflammation and interleukin 37 as an anti-inflammatory marker in patients with CIN after administration of contrast media.

It was as crossectional study, subject of study were were all affordable populations who underwent Percutaneus Coronary Intervention (PCI) at the Cardiac Installation Center of Wahidin Sudirohusodo Makassar (as many as 30 patients). Healthy people used as control of study (10 people) and also AKI patients (10 people).

Data indicated that both Non CIN and CIN groups had statistically significant IL-18 increases but decrease IL-37 even unsignificantly Data after media contrast administration showed that IL-18 of the control group differed significantly with CIN and AKI groups and did not differ significantly with non-CIN groups. After media contrast administration also showed that the IL-37 of control group differed significantly with AKI groups only and did not differ significantly with non-CIN and CIN groups.

Proinflammation activity, marked by IL-18 increased significantly after contrast administration but anti-inflammatory, marked by IL-37 decrese even unsignificatnly.