The Effectiveness of the Use of Propolis toward the Number of Polymorphonucleas Cells in Mice Wounds

Propolis is a honey bee product with a very complex chemical composition, made by gummy and balsamic materials collected by bees from sprouts, flower buds, trees and other vegetal-tissue resinous trees. Propolis is useful as an antibacterial, antifungal and anti-inflammatory. During inflammation, polymorphonuclear migration to the wound area increases and propolis acts to suppress the amount of polymorphonuclear in the wound.

To know the effectiveness of propolis to decrease the migration of polymorphouclear neutrophil cells to the wound in mice.

Experimental research with post-test only design with group control design. Propolis taken from the forest then made an extract with a concentration of 80% and then the mice were inserted with a wound depth of 2 mm and a wound length of 15 mm. Cut wounds of mice smeared with 80% propolis extract twice a day and then sacrificed 3 mice for check-up on days 1, 3, 5, and 7. Then histology was examined. Statistical analysis was performed by Mann Whitney test.

There were significant differences between treatment groups and control groups.

Propolis extract with 80% concentration has an influence on suppressing the amount of polymorphonuclear migration to the inflammatory area.