1Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq
*Corresponding Author: Hasanain Abdulhameed Odhar, Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq, Phone: 009647725300923, Email: hodhar3@gmail.com
Online published on 23 December, 2019.
Irritable bowel syndrome (IBS) is a chronic gastrointestinal condition mainly manifested by abdominal pain, discomfort and alteration in gut habits. Therapeutic approaches are mainly focused on symptoms mitigation and modification of life style. It was believed that GIT infection, inflammation and changes in mucosal flora may be involved in IBS development. Abnormal modification of gut-nervous system interaction may be also implicated. Helicobacter pylori (H. pylori) is a well-known cause of peptic ulcer with greater prevalence in developing communities. Some studies have linked this gram negative bacterium with several extra-gastric diseases like pre-eclampsia. It was proposed that infection with H. pylori can initiate systemic inflammation leading to IBS development through alterations in gut permeability, normal flora and interaction with nervous system. However, the precise association between IBS prevalence and H. pylori infection is still controversial. The aim of current study was to evaluate any possible relationship between irritable bowel syndrome prevalence and Helicobacter pylori seropositivity.
Lateral flow immunochromatographic assay was employed to screen 30 IBS patients and 30 control (without IBS) volunteers for H. pylori IgG antibodies.
Our regression analysis didn't show any significant association between irritable bowel syndrome prevalence and H. pylori seropositivity.
Irritable bowel syndrome, Helicobacter pylori, nervous system, seropositive, flow immunochromatographic assay
