Lecturer, Training and Development Department, DNA Forensic Center for Research and Training, AL-Nahrain University, Baghdad, Iraq
Polycystic ovary syndrome prevalence among young females is 15%. Sex hormones regulate immunity through hormone receptors on immunocytes. In addition, cytokines, commonly called interleukins, participate in ovarian cycle regulation. Major source of interleukin-17 is T helper 17 cells. Current study was aimed to investigate relationship between testosterone levels with interleukins levels, body mass index and polycystic ovary syndrome symptoms.
Twenty-six infertile polycystic ovary syndrome women were enrolled. Serum testosterone levels and serum levels of interleukin-1β, -17, -27 and-35 were measured on day 2 of the cycle.
There was significant correlation between elevated body mass index and high testosterone levels [p=0.0001]. in addition, recognizable impact of high testosterone concentrations was on incidence of hirsutism, alopecia, acne regularity of menstrual cycle [p=0.0006, p=0.002, p=0.006, p=0.04], respectively. Compared with normal testosterone levels, high testosterone levels caused significant decrease in interleukin-1β levels [p=0.002]; whereas interleukin-17 and interleukin-27 showed comparable results [p=0.36, p=0.09]; and non-significant increase in interleukin-35 in high testosterone levels [p=0.25].
Testosterone levels had significant impact on BMI, PCOS symptoms and serum interleukins levels.
Body Mass Index, Polycystic ovary syndrome, alopecia, acne, interleukins, testosterone
