The Role IL-16 rs11556218 T/G Gene Polymorphism with the Risk of Osteoporosis in a sample of Iraqi Postmenopausal Women

Interleukins (ILs), a multifunctional cytokines. It's play a fundamental role in inflammatory diseases, as well as in the development of osteoporosis and there are data about the role of IL-16 polymorphism in development of postmenpausal osteoporosis.

In this study, we investigated about the IL-16 rs11556218 T/G polymorphisms and the risk of osteoporosis among 50 patients with osteoporosis and 40 healthy controls. Serum IL-16 level and its correlation with the IL-16 rs11556218 T/G genotypes were analyzed.

Significant differences of genotype distribution were observed between osteoporosis patients and controls at the IL-16 rs11556218 T/G genotypes. Compared with the IL-16 rs11556218 T/G homozygote TT, the heterozygous TG genotype was associated with significantly increased risk for osteoporosis (X²= 13.25, OR = 5.52, p = 0.00048); the GG genotype was not significantly different from controls, this may be due to the number of samples collection or samples ethics. But the odds ratio appear a high risk factor (O.R.) of osteoporosis among people who having GG genotype (X²= 1.35, OR = 2.59, P = 0.292). In addition allele frequency for G allele associated with significantly increased risk for osteoporosis (x²=16.78, OR=3.94, p=<0.0001). TG and GG combined variants were associated with increased risk for osteoporosis compared with the TT genotype (X²= 10.98, OR =4.33, P = 0.0013). Moreover, in patients with osteoporosis, there was a correlation between the serum IL-16 and rs11556218 T/G genotype.

our study provided the evidence of association the polymorphisms of IL-16 rs11556218 T/G genotype and the risk of osteoporosis and found the IL-16 rs11556218 T/G genotype was associated with increased risk for development of osteoporosis in Iraqi postmenopausal women.