1Pharmacy, College of Pharmacy, University of Baghdad, Iraq
2PhD, Department of Chemistry and Biochemistry, Immunology and Molecular Biology, Al-Nahrain University, Iraq
3Department of Internal Medicine, FICMS, CABM. Al-Nahrain University, Iraq
*Corresponding Author: Moayed Basheer Hamid, Department of Internal Medicine, FICMS, CABM. Al-Nahrain University, Iraq, Email: qaisajam1981@gmail.com
Online published on 23 December, 2019.
Many study had tried to investigated the gene that associated with coronary heart disease and its complication, the danger of atherosclerosis and complication may increase as result of oxidization of low density lipoprotein by lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) which found as cell surface endocytosis searcher receptor, the aim is to explore whether or not the LOX-1 gene and it's 3’UTR C188T (rs1050283) polymorphisms were a genetic risks of ACS in sample of Iraqi population.
A case control study in which 3`-UTR188 C/T single nucleotide polymorphism (SNP) of LOX1 were studied in 100 Iraqi subjects: 35 with ACS, 30 have chronic stable angina, and 35 control subjects without CAD. DNA amplification refractory mutant system polymerase chain reaction method was performed the genotyping.
significantly not associated between 3`-UTR188 C/T SNP and the prevalence of ACS among the study groups.
3`-UTR188 C/T SNP polymorphism in the clinical practice not useful to evaluate the risk for ACS.
Acute coronary syndromes, Lectin-like oxidized low-density lipoprotein receptor-1 polymorphism, soluble LOX-1, 3`-UTR188 C/T (rs1050283) polymorphism
