Investigation the Role of Lactobacillus ssp. on Entamoeba histolytica Pathogenesis

Entamoeba histolytica is a type of parasite with global distribution. Infection with parasite causes amoebiasis which is responsible for more than 100, 000 deaths each year, that marking it the 3rd leading cause of death. Presence of parasite leads to kill host cells because of the cytotoxic activity of the parasite. 157 stool samples were collected from AL-Kindi teaching hospital and Fatima Zahara hospital in Iraq. The cysts of Entamoeba histolytica were isolated from the feces and inoculated the mice with cysts. After 3 days the mice infected with parasite. The infected mice showed the presence of trophozoites in the larger intestine and found in the larger intestine many histological abnormalities, while in serum of the infected mice the level of IL-10 and IFN-γ were high compared with uninfected mice, mice treated with Lactobacillus acidophilus and mice treated with metronidazole.