Sera Troponin-I Levels in Rheumatoid Arthritis Patients

Rheumatoid arthritis (RA) define as chronic inflammatory disease with autoimmune pathogenesis disease which affects nearly 1.5% of the community. Cardiac troponin-I (cTnI) is falsely elevated in patients with seropositive rheumatoid arthritis.

Determine if rheumatoid arthritis patients with seropositive and seronegative have unusually raised concentrations of cardiac troponin-I (cTnI), in order to find out if this cardiac marker is elevated or not and its association with other inflammatory diagnostic markers.

Serum samples were drawn from early diagnosis patients with RA groups 110 (60 without treatment group;50 treated group) and (30) subjects as healthy control group. cTnI levels measured by using Immunoassay System.

Forty nine of the 73 patients with seropositive RA had cTnI levels upper than 0.8 ng per ml that had no significant difference P=0.062, while 11 of the patients with seronegative RA levels above this value and P-value in this group non-significant P= 0.350. With RF+/-the sensitivity of troponine-1 was 100%, but the specificity with rheumatoid factor (RF)+ve 20% while with RF_ve 100%. The correlation of troponine-1 with other studied marker had high significant value P<0.05.

cTnI quantification was create more in patients with seropositive RF than patients with seronegative RF with no significant difference among studied groups, this recommends that inflammation might not be the primary driver of troponin raise in RA.