Indian Journal of Public Health Research & Development
  • Year: 2019
  • Volume: 10
  • Issue: 10

The Association between (CT60) Cytotoxic T-lymphocyte Antigen-4 Gene Polymorphism with its Plasma Levels in Alpecia Areata Patients

  • Author:
  • Sarah Isam Al-Rubaye1, Abdulsamie Hassan Alta'ee1,, Zena Saeed Al-Fadhily1
  • Total Page Count: 4
  • Page Number: 2882 to 2885

1College of Medicine, University of Babylon, Iraq

*Corresponding Author: Abdulsamie Hassan Alta'ee, College of Medicine, University of Babylon, Iraq, P. Code 51002, Hilla PO Box 473, Iraq, Email: abdulsamie68@gmail.com

Online published on 23 December, 2019.

Abstract

Alopecia areata (AA) is a dermatological disease featured by non-scarring hair loss of the scalp and/or body, with a variable and unpredictable development in the patients in whom, despite diverse efforts, its cause is not yet fully known, some signs suggest that genetic, environmental and immunological factors may cause the disease. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) said negative T cell proliferation regulator by attenuating either T-cell response post-activation or by preventing the activation of self-reactive T cells. The present study, aims to report the impact of the (CT60) CTLA-4 gene polymorphism (rs3087243) on the CTLA-4 levels in plasma samples of AA Iraqi patients.

Keywords

Alopecia areata, Hair loss, CTLA-4, CT60 Polymorphism