Study the Levels of Thyroid Hormones in Graves’ Disease and Impact on Leptin and Resistin Levels

The objective of the study is to assess the clinical execution in Graves’ disease. We tested sera of patients with thyroid diseases and estimated (TSH), free thyroxine (FT4), thyroperoxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb) also Leptin and Resistin. A total sera of 40 successive patients (25 females and 15 males) and 35 healthy subjects (20 females and 15 males) with aged between 30–65 years were assessed. The result of this study showed the increase in serum level of resistin in patients with thyroid dysfunction. The results showed that serum leptin levels were significantly low (P<0.004) in hyperthyroid patient groups as compared to control. Resistin hormones levels increased non-significantly (P˃0.05) than control levels. They affects each other in their physiological function in the human body. We concluded that (TgAb)) and (FT4) high this leads to changes in levels of thyroid hormones and the result of this study showed the increase in serum levels of resistin in patients with thyroid dysfunction.