1College of Science, University of Babylon, Hilla, Iraq
2Department of Scholarships and Cultural Relations, Ministry of Higher Education and Scientific Research, Baghdad, Iraq
Online published on 23 December, 2019.
Aluminium chloride is a neurotoxic metal that induce several neurodegenerative diseases such as anxiety, depression and Alzheimer diseases. The aim of this study designed to investigate the effects of aluminium chloride on some behavioral and physiological parameters of male rats.
Twenty one male rats were used in this study and divided to three groups with seven rats for each group, included untreated control group received distilled water and two treated groups that received aluminium chloride at the doses 300 mg/kg and 400 mg/kg of body weight orally and daily for 60 days, the following behavioral parameters measured by using Elevated Plus-Maze test.
Administration two different dose of Al for eight weeks of rats in group II and group III causing significantly reduced in brain monoamine oxidase A and neurotransmitters levels (serotonin and dopamine), In addition, Al causing also significantly decreased in serum hormones (testosterone, corticosterone and LH) compared to control group I. The results showed significantly suppressed of the sexual behavior and memory disorders of rats that exposure to aluminium compared to control group. In conclusion, Aluminum enhances depression and anxiety parameters and cognitive disorders characterized by the affection of memory.
Aluminum, Depression, Anxiety, Memory, Rat, serotonin, dopamine
