Application of Silver Nanoparticles (Silver NPs) in Assisted Reproductive Techniques (ART) as a Carrier Vehicles to Improve the Therapeutic Influence of Doum Extract for Sperm of Asthenozoospermic Patients

Assisted reproductive techniques are a tool practiced worldwide to help couples achieve pregnancy and preserve fertility. However ART reveals several limitations which needs for new alternatives to overcome these limitations. Over recent years, nanotechnology has been applied as a tool to improve strategies to enhance the outcome of ART. This study has investigated for the first time the impact effect of implication of silver NPs to boost therapeutic effect of Doum palm (HyphaeneThebaica) extract on enhancing sperm quality of asthenozoospermic patients. The findings of this study has showed the implication of silver NPs has significantly enhanced theSuperoxide dismutase activity, and reduced Malondialdehyde expression and sperm DND fragmentation percentage. These encouraging results suggest that nanotechnologies could be easily included in the routine procedures of ART to improve sperm quality and thus increase the rate of successful pregnancy and preserve fertility.