MMP-13 Gene Polymorphisms Associated with KOA in Iraqi Population

Knee osteoarthritis (KOA) is disease occur in knee joint characterize by cartilage degradation that mediate via pro-inflammatory marker such as matrix metalloproteinase-13 (MMP-13). MMP-13 is enzyme expression in chondrocyte, encoded by MMP-13 gene, act to degraded it and joint degenerative. This study explained association the rs2252070 single nucleotide polymorphisms (SNP) of MMP-13 gene in KOA. The result demonstrate that G alleles have significant association with KOA development. our results are the first ones reporting an association between MMP-13 and KOA in Iraqi populations.