Evaluation of Serum IL-21, TNF-α and hsC-Reactive Protein in Patients with Chronic Periodontitis

Chronic inflammation isthe hallmark of periodontitis. The inflammatory events are suggested by the action of microbes in tissue cells that lead to release of several cytokines and soluble mediators. Among them TNF alpha and Interleukine-21 are known to play an important role. C-reactive protein is an acute phase protein, highly sensitive marker used to indicate inflammatory tissue. This study evaluates serum levels of Il-21, TNF α, hsC-reactive protein in patients with chronic periodontitis and periodontally healthy individuals. Total 46 participant, 30 cases of chronic periodontitis, 16 systematically healthy subjects, with age and sex matched were included in study. The serum levels of IL-21, TNF alpha, were assessed by using Enzyme Linked immunosorbant assay. hsC-reactive protein assessed by particle enhanced immunoturbidometer. Statistical analysis was performed using statistical software. Data were expressed as mean ± SD and interquartile ranges and comparison of controls and cases by Mann Whitney Test. Levels of IL-21, TNF α, hsC-reactive protein were notably higher in chronic periodontitis group than control. (p<0.001). IL-21, TNF α, hsC-reactive protein, highly expressed in patients with chronic periodontitis than control subjects and linked. Therefore these markers can be used for diagnosis of chronic periodontitis.