1Research Scholar, Department of Pediatrics, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
2Research Scholar, Institute of Biochemistry, Madras Medical College & RGH, Chennai, Tamil Nadu, India
3Associate Director, Department of Pediatrics, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
4Junoir Research Scientist, Research & Development Wing, Department of Pediatrics, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
5Professor, Department of Pediatrics, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
6Professor, Institute of Biochemistry, Madras Medical College & RGH, Chennai, Tamil Nadu, India
7Assistant Professor, Department of Human Genetics and Molecular Biology, Bharathiyar University, Coimbatore, Tamil Nadu, India
*Corresponding Author: Dr. G. Bupesh, Associate Director, R & D Wing, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai-73, e-mail: bupeshgiri55@gmail.com, Mobile: 8012405965
Online published on 27 March, 2020.
The present study was conducted to assess the Urinary iodine excretion levels among hypothyroid patients based on Thyroid profile and to correlate the Urinary iodine excretion with various disorders associated with hypothyroidism.
The study group includes 50 control subjects and 100 clinically proven hypothyroidism patients. Histopathological investigations and thyroid scan were taken for all the patients. They were analyzed for Thyroid hormone profile and the Urinary iodine excretion level was determined by Ammonium persulfate method in spot urine sample.
Free T4, TSH and Urinary iodine concentration (UIC) were measured for both the control and study group (P = 0.00).The mean Free T4, TSH & UIC for control group was 1.71 ng/dl, 1.41μIU/ml & 150.28μg/L and the mean Free T4, TSH & UIC for test group was 0.85ng/dl, 48.38μIU/ml & 233.74μg/L respectively. A significant positive correlation between Free T4, TSH and UIC was found. Increased Urinary iodine excretion (UIE) was observed in patients with Papillary Carcinoma, Thyroiditis and Multinodular goiter.
The findings of the present study reveals that increased excretion of urinary iodine reflects under utilization or impaired iodination by the thyroid gland.
Hypothyroidism, Urinary iodine, Iodine deficiency disorders, Goitre
