1Student, Doctor of Public Health Program, Faculty of Public Health, Khon Kaen University, 123 Moo 16 Mittapap Rd Nai-Muang, Muang District, Thailand
2Associate Prof., Advisor, Faculty of Public Health, Khon Kaen, Thailand, 123 Moo 16 Mittapap Rd Nai-Muang, Muang District, Thailand
3Professor, Head, Department of Public Health, Post-graduate Program, Universitas Sebelas Maret, Indonesia
4Jalan Ir. Sutami 36 Kentingan, Jebres Kota Surakarta, Jawa Tengah, Indonesia
5Lecture, Sirindhorn College Khon Kaen, 90/1 Anamai, Tambon Nai Mueang, Amphoe Mueang Khon Kaen, Chang Wat Khon Kaen, Thailand
*Corresponding Author: Wongsa Loahasiriwong, Faculty of Public Health, Khon Kaen University, Thailand-40002, e-mail: drwongsa@gmail.com
Online published on 27 March, 2020.
The burden of tuberculosis (TB) is exacerbated by anti-TB drug resistant especially multidrugresistant TB (MDR-TB). There has been an increasing trend of Multidrug-resistant TB in Indonesia. However, there is lack of epidemiological study on risk factors of MDR-TB in Indonesia.
This study aimed to determine the influence of TB treatments as risk factors on MDR-TB in Central Java Indonesia while controlling other covariates.
A case-control study was conducted between August 2017 and February 2018. The study subjects were selected using inclusion criteria. Cases were 81 MDR-TB patients in intensive phase that lived in Central Java and recorded in the Moewardi Hospital, a referral hospital. The controls were 228 patients who received first-line anti-TB treatment without drug resistance. A structured questionnaire interview was used to collect the data. Multiple logistic regression analysis was used to identify the association.
The proportion of gender among the 81 cases and 228 controls were 64.2% vs. 43.0% for males, and 35.8% vs. 57.0% for females. TB treatment that were significantly associated with MDR-TB were: length of TB treatment > 6 months (aOR =14.1; 95% CI: 6.68–29.86), continued TB treatment (aOR =11.695% 95%CI: 5.36–25.48). Other significant covariates were had no formal education or primary education (aOR = 2.89; 95% CI: 1.38–6.02) and low monthly income (aOR =2.86; 95%CI: 1.18–6.92)
Long duration, discontinuity of TB treatment, and low socioeconomic status increase the risk of MDR-TB.
Multidrug resistant tuberculosis, MDR-TB, risk factors, Central Java, Indonesia
