1Associate Professor and Head, Human Genetics Laboratory, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
2Research Assistant, Human Genetics Laboratory, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
3Professor, Department of Life Science, School of Natural Sciences, University of Suwon, Wau-ri, Bongdam-eup, Hwaseong-si, Gyeonggi-do, Republic of Korea
*Corresponding Author: Dr. Usha Subbiah, Human Genetics Laboratory, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai-600 100, Tamil Nadu, India, Tel: +91 8248707203, Fax: +91 044 22460631, e-mail: ushat75@yahoo.com
Online published on 27 March, 2020.
Saliva, the “mirror of the body, ” is an ideal non-invasive source of complex genetic information. The complexity of the salivary peptidome is mainly due to the high number of genetic polymorphisms. This review shows an association between the genetic polymorphisms of salivary secretory proteins and the endangerment of several diseases. Different secretory protein single nucleotide polymorphisms whose genetic positions are related to oral and other diseases are listed from SNPedia deposits and tracked using a variety of techniques. Besides being circulating salivary biomarkers, single nucleotide polymorphisms of salivary secretory proteins acts as a possible genetic susceptibility factor and aids in the early detection and prevention of various oral and systemic diseases including cancer and rare syndromes in a quick and non-invasive manner. This would pave the way for the development of array-based technologies using saliva sample for genetic analysis.
Single nucleotide polymorphism, Saliva, Secretary proteins, Oral diseases
