Oral Submucous Fibrosis: A Review on Etiopathogenesis and Recent trends in Management

Oral submucous fibrosis is an incidious, chronic disease stirring any part of oral cavity and sometimes the pharynx. South east Asian counties are proven to be high prevent zones.for oral sub mucous fibrosis.. Areca quid related oral mucosal lesions are potential hazard to an outsized e population worldwide. Commercially freeze dried products such as pan masala, guthka and mawa have high concentration of areca nut per chew and appear to cause osmf more rapidly than by self prepared betel quid that contain smaller amounts of areca nut. These chemicals appear to interact with the molecular processes of deposition and or degradation of extracellular matrix molecules such as collagen causing imbalance in the regular process. Various studies done in the past include osmf as potentially malignant disorder. Understanding the etiopathogenesis of osmf may be beneficial to revert the risk factors thereby minimizing the progress of the disease which is included as the priority in the prevention of disease.