Indian Journal of Public Health Research & Development
  • Year: 2019
  • Volume: 10
  • Issue: 11

Expression of Ki-67 AND Bcl-2 in Endometrial Hyperplasia

1Post Graduate, Department of Pathology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai

2Associate Professor, Department of Pathology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai

3 Professor and Head, Department of Pathology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai

*Corresponding Author: Dr. Hemalatha Ganapathy, Professor and Head, Department of Pathology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai-73. E Mail- hemalathagnpthy@yahoo.com, M No- 9444108134

Online published on 27 March, 2020.

Abstract

Prolonged oestrogen exposure can induce exaggerated endometrial proliferation (hyperplasia), which is an important precursor of endometrial carcinoma1. This investigation uncovered that both HER2/neu cynicism and energy were similarly pervasive in both the wide age gatherings (<=50 years and >50 years). It demonstrated that HER2/neu energy was similarly circulated between T1, T2 and T3 sores of bosom carcinoma. Dominant part of the instances of obtrusive ductal carcinoma of no extraordinary kind were sure for Her 2/neu. None of the other histological sorts indicated HER2/neu inspiration. Thinking about the little quantities of instances of obtrusive lobular carcinoma, mucinous carcinoma, metaplastic carcinoma of no unique kind and intrusive papillary carcinoma, the nearness or nonappearance of relationship of HER2/neu articulation with the histologic sort can't be finished up. The present examination showed higher indication of HER2/neu energy in evaluation II, trailed by evaluation I and grade III cases. It likewise indicated more instances of AJCC arrange II tumors being sure for HER2/neu than AJCC organize III tumors. The present examination had no tumors of AJCC stages I and IV. HER2/neu inspiration has additionally been seen as related with positive lymph hub metastatsis status than negative lymph hub metastasis status.

Keywords

Mucinous carcinoma, metaplastic carcinoma