Indian Journal of Public Health Research & Development

  • Year: 2019
  • Volume: 10
  • Issue: 11

Change of Histological Shape and Gene Expression of Thymosin β4, c-Myc, Erb-B2 and TGF-β1by Acute Hepatotoxicity

1Department. of Clinical Laboratory Science, Daejeon Health Institute of Technology, South Korea

2Department. of Physical Therapy, Sun Moon University, South Korea

*Corresponding Author: Dong-Yeop Lee, kan717@hanmail.net

Online published on 27 March, 2020.

Abstract

The aim of this study was to evaluate the expression of TGF-β1, C-Myc, Erb-B2 and Thymosin-β4 in acute hepatotoxicity.

The test method produced an acute hepatic model by oral administration to 10-week-old BALB/c using CCl4 and studied changes in the gene expression of TGF-β1, C-Myc, Erb-B2, and Thymosin-β4 through real-time PCR.

The results showed that the histological changes and the expression of Thymosin β4, C-Myc, and TGF-β1 gene were higher in liver injury than normal tissues.

In addition to serological and systematic examination in the prevention and determination of liver function-related diseases, genetic expression by molecular diagnostic techniques of TGF-β1, C-Myc and Thymosin-β4 could be used as an aid in liver disease determination.

Keywords

C-Myc, Masson trichrome, Hematoxylin, Erb-B2, Thymosin-β4