1Department. of Clinical Laboratory Science, Daejeon Health Institute of Technology, South Korea
2Department. of Physical Therapy, Sun Moon University, South Korea
The aim of this study was to evaluate the expression of TGF-β1, C-Myc, Erb-B2 and Thymosin-β4 in acute hepatotoxicity.
The test method produced an acute hepatic model by oral administration to 10-week-old BALB/c using CCl4 and studied changes in the gene expression of TGF-β1, C-Myc, Erb-B2, and Thymosin-β4 through real-time PCR.
The results showed that the histological changes and the expression of Thymosin β4, C-Myc, and TGF-β1 gene were higher in liver injury than normal tissues.
In addition to serological and systematic examination in the prevention and determination of liver function-related diseases, genetic expression by molecular diagnostic techniques of TGF-β1, C-Myc and Thymosin-β4 could be used as an aid in liver disease determination.
C-Myc, Masson trichrome, Hematoxylin, Erb-B2, Thymosin-β4
