Indian Journal of Public Health Research & Development

  • Year: 2019
  • Volume: 10
  • Issue: 11

Physical, Biological and Antimicrobial Properties of Polymethyl Methacrylate Coated with Cnidium Officinale Extract

1Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea

2Department of Dental Hygiene, Hanseo University, 46 Hanseo 1-ro, Haemi-myun, Seosan-si, Chungcheongnam-do, 31963, Republic of Korea

Abstract

This study was aimed to investigate the influence of Cnidium officinale (CO) extract coating on the physical, biological, and antimicrobial properties of polymethyl methacrylate (PMMA) surface.

PMMA was coated with CO extract of different concentrations and tested for physical properties such as microhardness, water contact angle, and color change, and cytotoxicity measured through MTT assay. Antimicrobial and antifungal activity was measured against Streptococcus mutans and Candida albicans. Polyphenol content in the extract was analyzed using a UV-vis spectrometer. The results were analyzed by one-way ANOVA followed by Tukey's test.

There were no significant differences in microhardness, contact angle, color change, and cell viability (p > 0.05) between control and CO-coated PMMA samples. However, the CO-coated groups showed significant reduction in Streptococcus mutans and Candida albicans (p < 0.05). CO significantly improved the antimicrobial effect of the denture, consistent with its polyphenol content.

Our results indicate that coating PMMA resin with CO extract would be effective for ensuring good antimicrobial activity, while maintaining the advantages of PMMA.

Keywords

Antimicrobial property, Biological property, Cnidium officinale, Extract, Physical property,