Clinical Efficacy and Anti-Inflammatory Property of Curcumin in Periodontal Disease: A Systematic Review

Periodontitis is a chronic inflammatory condition, caused by bacteria, that leads to the destruction of supporting tissues around teeth, resulting ultimately in significant morbidity as a result of infection, pain and tooth loss. Curcumin, from the root of the turmeric plant Curcuma longa, is an extended pseudo symmetric polyphenol. In recent years, in vitro and in vivo research has suggested that curcumin has anticarcinogenic, antiviral, antioxidant and anti-inflammatory effects. The aim of this review is to systematically evaluate the clinical efficacy and anti inflammatory property of curcumin in periodontal disease. An electronic search was carried out using the keywords ‘curcumin’, ‘periodontal’ and ‘periodontitis’ via the PubMed/Medline, ISI Web of Science and Google Scholar databases for relevant articles published from 2009 to February 2019.