A Comparative Evaluation of Antibiotic Susceptibility Pattern of Methicillin Sensitive and Methicillin Resistant Staphylococccus Aureus Isolated from Clinical Specimens in a Tertiary Care Hospital

Staphylococcus aureus is a major human pathogen that causes a variety of suppurative (pus-forming) infections had evolved as a major cause of hospital acquired (nosocomial) infection humans. MRSA, a resistant variant of Staphylococcus aureus is resistant various classes of antibiotics such as penicillins, methicillin, cephalosporins and the fluoroquinolones, it is often reflected as a superbug. Methicillin-resistant Staphylococcus aureus (MRSA) posed to be an uncontrollable, nuisance in serious public concern. Vancomycin, a glycopeptides is the treatment of choice for MRSA infections. In recent times development of vancomycin resistant Staphylococcus aureus (VRSA), strains all around the world with highest being reported in health-care settings, the alternatives are Oxazolidons which includes Linezolid and polycyclic compounds such as Tetracycline and Tigecycline.

A total 620 Staphylococcus aureus isolates employed in this study was conducted at Department of Microbiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry All the isolates were collected between July 2014 to April 2017 in the study. All the isolates were identified as S. aureus by culture and biochemical tests which included test for clumping factor, free and bound coagulase and mannitol fermentation.

The average resistance seen in Ampicillin(93.8%), Cephelexin(88.6%), Cefotaxime(86.4%), Cloxacillin (17.9%), Erythromycin(82.4%), Gentamicin(10%), Ciprofloxacin(50.2%), Clindamycin(44.6%), Penicillin(90.5%), Tetracycline(84.8%).

The present study shows health care institutions face constant and evermore problems because of Staphylococcus aureus. Active screening and proper infection control procedures need to be adopted to control Staphylococcus aureus infection.