1Department of Chemistry and Biochemistry, College of Medicine, Al-Mustansiriyah University, Baghdad, Iraq
2Department of Medicine, College of Medicine, Al-Mustansiriyah University, Baghdad, Iraq
*Corresponding Author: Israa Abdelmalik Salem e-mail: esraaha2000@gmail.com, Tel: +964 07901580481
Online published on 8 March, 2019.
Apelin is a proinflammatory adipokine that can be induced by other inflammatory mediators. Periostin is produced by different types of tissue under the influence of inflammation and mechanical stress.
The aim of this study was to evaluate serum (Apelin, Periostin (POSTN), and Tartrate-resistant acid phosphates (TRACP)-5b among ankylosing spondylitis (AS) male patients with active and inactive disease and find the correlation between disease activity and the studied parameters.
Fifty-eight male Ankylosing spondylitis (AS) patients were included in this study. Serum Apelin, Periostin (POSTN), and tartrate-resistant acid phosphates (TRACP)-5b were measured using commercial enzyme-linked immunosorbent assay (ELISA) kits. Disease activity was determined by using a BASDAI score.
Ankylosing spondylitis (AS) male patients with active disease had a significantly high serum level of serum TRACP-5b (P-value <0.001) while serum of (Apelin and Periostin) levels shows no significant differences (P-value > 0.05) when to AS males with inactive disease.
The results of this study suggest that serum Apelin and periostin levels show no differences among AS male patients with active when compared to AS male patients with the inactive disease, but serum TRACP-5b was elevated in AS male patients with active disease. Correlations between disease activity (BASDAI score), and serum POSTN and with serum TRACP-5b have been found.
Ankylosing spondylitis, Apelin, Periostin, TRACP-5b, and BASDAI
