1Midwifery Program of Yaleka-Maro School, Merauke, Papua, Indonesia
2School of Post Graduate, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
3Midwifery Program of Medistra Health Higher School, Jakarta, Indonesia
4Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
5Department of Biochemistry, Bogor Agricultural University (IPB), West Java, Indonesia
6Department of Neurosurgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
7Department Nutrition, Faculty of Medicine, Halu Oleo University, Kendari, Indonesia
8Molecular Biology and Immunology Laboratory for Infectious Diseases, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Online published on 8 March, 2019.
The efficacy of red fruit (Pandanus conoideus) oil extract on CD4+ cells was evaluated in HIV infected patients with taking antiretroviral therapy.
Seventy patients with an age of 17–45 years, with confirmed HIV infection with a CD4 count of 200–349 cells/μL, were divided into the antiretroviral (ARV) control (n = 35) and the antiretroviral + red fruit capsule (ARV+RFC)-treated (n = 35) groups. In ARV+RFC group, they were given oral RFC (1 g daily for two months). Monitoring evaluations of the laboratory were performed at baseline (0 months) and two months during the study.
The result showed that the CD4+ cells count was increased in the patient who took ARV+RFC compared with ARV alone (P<0.05).
By these result, it can be concluded that the red fruit oil extract may have an excellent immunomodulatory impact and has potential as an adjuvant in the management of HIV patients.
Antiretroviral therapy, CD4+ cell, HIV/AIDS, Immune, Pandanus conoideus
