1M. Sc. Student in Clinical Biochemistry Dept., College of Medicine, University of Babylon, Iraq
2Clinical Biochemistry Dept., College of Medicine, University of Babylon, P.O. Box 473, Hilla, Iraq
3College of medicine, University of Babylon, Iraq
Online published on 8 March, 2019.
Lipoprotein lipase plays an important role in lipid metabolism. The aim of this study was to explore the possible associations of gene polymorphisms LPL-HindIII and diabetes mellitus with myocardial infarction.
The polymorphisms were assessed by restriction assay in 60 Iraqi MI patients, 60 patients with diabetes mellitus and 60 healthy controls.
This study demonstrated that individuals with the H2H2 genotype higher relative risk of suffering from MI than those carrying the H1H1. Type 2 diabetes mellitus had mainly lower HDL-C levels in MI patients who carry H2H2 genotype and higher TC, TG, and LDL levels in MI patients carrying H2H2 genotype.
These findings suggested that H2H2 genotype is associated with dyslipidemia and increased risk of myocardial infarction. The association of diabetes mellitus with this polymorphism leads to unfavorable lipid profile.
Lipoprotein lipase, genetic polymorphism, type 2DM. lipids profile, myocardial infarction
