1Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Kerbala, Iraq
2Department of Environmental Health, College of Applied Medical Sciences, University of Kerbala, Iraq
3Ministry of Health, Baghdad, Iraq
Online published on 8 March, 2019.
Organophosphorus compound is one of the most various collections of insecticides. Malathion is one of the organophosphorus insecticides. These days, there is great emphasis on recognizing the power of natural products of plants as chemopreventive substances which are found in foods and used by human beings. Therefore, the aim of current study was to define the impact of green tea against side effects of malathion.
Animals were divided into 3 groups (6 rats in each group). First group was used as a control group. The second group was given malathion (50mg/kg/day; which is 1/50 of LD50 for two weeks). The third group was given malathion (50mg/kg/day) plus green tea (50mg/kg/day) for two weeks each. At the end of the second week the group treated with malathion showed reduced White Blood Cells (WBCs), Red Blood Cells (RBCs), concentration of Hemoglobin (Hb), Hematocrit (PCV) and platelets count in comparison with control group. However, there were significantly high serum levels of uric acid and creatinine in malathion group than control group. Also, there is significant increase in malathion plus green tea group than malathion group for the same hematological parameters except WBC count and significant decrease in the levels of uric acid and creatinine in malathion plus green tea group than malathion group.
The present study recommended that using green tea is effective in decreasing the toxic effects of organophosphorus insecticides like malathion.
Malathion, green tea, blood indices, uric acid, creatinine
