Serum levels of Anti-Mullerian Hormone, Leptin, T3, T4 and TSH in Women with Polycystic Ovary Syndrome in Iraq

Endocrine abnormalities associated with polycystic ovarian Syndrome (PCOS) are essential problems. PCOS is a frequent trouble inflicting menstrual irregularity and infertility among women regarding effective age. Increased level of Anti-Müllerian Hormone (AMH) is presently considered an essential marker for PCOS. Aims of current study were to evaluate serum levels of AMH and to correlate them with age, BMI and serum levels of TSH, T3, T4 and leptin in females with PCOS as compared to normal controls.

Current study involved 120 females with PCOS belonging to age group (18–35) years from Misan City, Iraq. These patients were divided into three equal groups as follows: G1(controls), G2 (females having PCOS and hyperthyroidism) and G3 (females having PCOS and hypothyroidism).

Data from current study showed highly significant (P< 0.001) increase in age, BMI in G2 and G3 when compared with G1. Also, results showed non-significant increase in AMH in group G3 and G2 when compared with G1. The results also revealed significant increase in TSH, T3, and T4 in G2 and G3 compared with G1. In addition, there was highly significant increase in leptin hormone in G2 and G3 when compared G1. The results showed AMH was not related with age in G1 and patients groups. Also, there were non-significant correlations between BMI, TSH, T3 and T4 in G1 and patients groups. Also AMH showed negative correlation with leptin in G2, while non-significant positive correlation in control and G3.

PCOS women of fertile age have higher AMH, TSH, T3, T4 and leptin levels in patients groups than that of control. It can be considered as an important marker for the diagnosis of PCOS.