1Department of chemistry, College of Education for girls, University of Anbar, Ramadi, Iraq
2Department of chemistry, College of Science, University of Anbar, Ramadi, Iraq
3Department of Clinical Biochemistry, College of Pharmacy, University of Sulaimani, Sulaimani, Iraq
Online published on 8 March, 2019.
Breast cancer is the commonest cancer affecting women worldwide.
Different studies have dealt with the etiological factors of that cancer aiming to find a way for early diagnosis. The present study investigated the relationship between BMI and evaluation of some etiological risk factors among breast cancer patients in Iraq.
This investigation was carried out on 74 patients (all were females) who received satisfactory therapy. They were confirmed for breast cancer by histopathological examinations at Nanakali Hospital in Erbil, Iraq, and 30 of apparently healthy women were used as a controls. All women (patients and controls) were between 20–72 years. Age, weight, height, hormone receptors (ER, PR and Her2) were taken into account as risk factors.
Among the breast cancer patients, 45% were pre-menopausal, 28% were menopausal and 27% were post-menopausal. Body mass index (BMI) is widely used as a measure of obesity. We investigated the relationship between obesity (BMI >= 30 kg/m2) and outcomes in women with ER-positive early stage breast cancer.
Women with high BMI presented with more aggressive stage at the time of diagnosis. Their tumors usually show positive hormonal status as ER/PR), HR+/HER2 have being the most predominant molecular subtypes. Therefore, decreasing weight will mainly contribute to decrease tumor exposure to high endogenous estrogen especially in postmenopausal age, dramatically effect response to treatment in return.
Breast cancer, estrogen, BMI, Obesity, hormonal receptors
