1Department of Family and Community Medicine, College of Medicine, University of Al-Nahrain, Iraq
2Department of Basic Sciences, Faculty of Dentistry, University of Kufa, Iraq
3Department of Chemistry, College of Education, (Ibn-Al-Haitham) for pure Science, University of Baghdad, Iraq
Online published on 8 March, 2019.
Diabetic Nephropathy plays a key role in the function of kidneys to work for removing extra fluid and waste products from the body. The best way to prevent diabetic nephropathy is by maintaining a healthy lifestyle and treating diabetes and high blood pressure. Aim of the study was to locate the levels of Glucagon-Like Peptide-1 and Dipeptidyl Peptidase-4 in diabetic nephropathy patients and compare the results with the control group.
The study involved 30 healthy controls and 30 diabetic nephropathy patients. Blood samples were collected from healthy controls and diabetic nephropathy patients after 12–14 hours of fasting. The study was conducted between April 2015 and September 2015 in the diabetic & endocrinology center in Al-Sadder Medical City, Iraq. Whole blood used in determination of HbA1C. Serum was obtained from other part of blood that used in determination of FBG, Albumin, Urea, Creatinine, Total cholesterol, Triglyceride, high-density lipoprotein-cholesterol, GLP-1 and DPP-4. The levels of low-density lipoprotein-cholesterol and very low-density lipoprotein-cholesterol were analyzed by using Friedewald equation..
The results showed significant elevation in FBG, HbA1C, GLP-1 and DPP-4 levels in diabetic nephropathy group comparing to control group. There was illustrated significant increased in TC, TG, LDL-c and VLDL-c in diabetic nephropathy group comparing to control group, while a significant decrease was noticed in HDL-c level in the patient group compared with the control group. Also, results of current study revealed a significant decrease in Albumin levels in diabetic nephropathy group comparing to control group. Moreover, the study showed a significant increase in Creatinine, Urea and Blood Pressure Levels in diabetic nephropathy group comparing to control group.
There is significant association between Diabetic Nephropathy and raised FBS, HbA1C, GLP-1, DPP-4, TC, TG, LDL-c, VLDL-c, Creatinine, Urea levels and Blood Pressure and significant decrease in Albumin, HDL-c level in diabetic nephropathy group compared to control group. It is, therefore, recommended to use (DPP-4) inhibitors which stimulate insulin release and inhibit glucagon releaseng.
Diabetic Nephropathy, GLP-1, DPP-4, Creatinine, lipid profile
