1Department of Biology, Faculty of SciencesUniversity of Kufa, Najaf, Iraq
2Department of Ecology, Faculty of SciencesUniversity of Kufa, Najaf, Iraq
Online published on 8 March, 2019.
Non-steroidal anti-inflammatory drugs (NSAIDs) are prominent amongst the most generally endorsed solutions for extensive variety of musclo-skeletal (MSK) tissue disorders. Additionally, different NSAIDs, apart from diclofenac, may cause gastrointestinal ulceration, extreme harm in testis, renal, liver tissues and serious hematological problems. The aim of current study was to study the influence of diclofenac sodium in the male rat fertility.
This study involved 20 rats divided into four groups, each of five rats, as control and three active groups. The latter were treated with intramuscular diclofenac (50, 100 and 150mg/kg body weight) for 21 days.
The results showed a significant (p<0.05) decrease in rats’ testes weights as compared with controls. In addition, testes from diclofenac-treated rats showed variable dose-dependent pathological changes that were revealed under light microscopy.
Pathologically testicles damage related with NSAIDs isn't pervasive, however, we think it is interesting to report these findings for the recognition of the histopathological changes over the duration of diclofenac cytotoxicity.
Diclofenac sodium, male rats, testis, Sertoli cells, spermatogenesis, infertility
