Indian Journal of Public Health Research & Development
  • Year: 2019
  • Volume: 10
  • Issue: 3

The Role of Vitamin D Suplementation in Allergic Rhinitis Management

  • Author:
  • Abdul Qadar Punagi1, Stella Fitrianty Attu1,, Sutji Pratiwi Rahardjo1, Firdaus Hamid2, Ilham Jaya Patellongi3
  • Total Page Count: 5
  • Page Number: 574 to 578

1Department of ear, Nose, Throat, Head-Neck Surgery, Medical Faculty, Hasanuddin University, Makassar, Indonesia

2Department of Microbiology, Hasanuddin University, Makassar, Indonesia

3Departmen Physiology and Statistic, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

*Correspondent Author: Stella Fitrianty Attu Department of ear, Nose, Throat, Head-Neck Surgery, Medical Faculty, Hasanuddin University, Makassar, Indonesia, Phone: 081242327830, Email: stellafitrianty01@gmail.com, yurniati.nurung7@gmail.com

Online published on 20 March, 2019.

Abstract

In recent years, the increase in the incidence of allergic diseases worldwide is often associated with vitamin D deficiency. This study aimed to see the effect of additional therapy of vitamin D on the specific immunoglobulin E (IgE) levels of allergic rhinitis patients.

It was an experimental research with pre and post test design group control design. This study involved 40 patients with allergic rhinitis that positive for Der p allergen in skin prick test, divided into 2 groups. Group I was 20 patients receiving intranasal fluticasone spray and vitamin D 2x400IU/day for 21 days. Group II is 20 patients who only get fluticasone intranasal spray therapy for 21 days. Both groups of patients examined the levels of 25(OH)D and specific IgE Der p pre and post therapy.

Examination of 25(OH)D and specific IgE Der p was done by enzyme-linked immunosorbent assay (ELISA) method. From the analysis of demographic characteristics of the subjects in each group showed no significant difference (p> 0.05) between the two groups based on sex and age of the patient. The results of the Mann-Whitney test showed significant difference (p <0.05) between the two groups, where the specific IgE level decreased more in the vitamin D group than in the non-vitamin D group.

There is a significant correlation between changes in levels of 25(OH)D and specific IgE Der p levels of patients with allergic rhinitis, where the increasing levels of 25(OH)D caused decreasing of specific IgE Der p levels.

Keywords

Allergic Rhinitis, Vitamin D, 25(OH)D, Specific IgE Der p