A Community-Based Study on the Association Helicobacter pylori seropositive to upregulate Cyclooxygenase 2 (COX2) Expression

Helicobacter pylori infection can induce chronic inflammation and impact to release NFkB, and other pro inflammatory cytokine such as cyclooxygenase 2 (COX2). COX2 is a catalisator enzyme to arachidonic acid metabolism. Increase expression COX 2 lead to manifestation of extragastric. Acute Helicobacter pylori inflammation wheather also can induce upregulate express ion of cyclooxygenase 2 (COX2) is still unclear. This study aimed to evaluate wheather acute Helicobacter pylori infection also can induce upregulate expression COX 2. This research was cross-sectional study conducted from march to june 2018. The inclusion criteria were an age between 17–19 years girl, post menarche, and absence of pregnancy. Ultimately, 105 girl were enrolled in this study. Our procedure is an advance onn current methods and useful ELISA measurement of Ig M and Ig G antibodies diagnosed with Helicobacter pylori. ELISA measured serum Cyclooxygenase 2 (COX2) level. Among the subjct, forty-five (42.8%) had been diagnosed with Helicobacter pylori infection based on Ig M Helicobacter pylori seropositive. Otherwise Ig G Helicobacter pylori seems to be normal. The subjects with Helicobacter pyori infection had higher mean COX 2 than those without Helicobacter pylori infection (2.5 ± 1.1 vs 0.6 ± 0.4, P = 0.001). This study can conclude that subjects with Helicobacter pylori infection may increase a risk of upregulate COX 2 even in acute inflammation. this results will give a new understanding about pathophysiology of Helicobacter pylori infection.