1College of Medicine-Department of Chemistry and Biochemistry, Mustansiriyah University, Baghdad
2National Diabetes Center-Mustansiriyah University, Baghdad
*Corresponding Author, Raghd A.Y. Alkhader, E-mail: raghad.adnan20@gmail.com, Tel No: 07713663258
Online published on 6 April, 2019.
Betatrophin, have been identified as hormone produced in adipose tissue and liver, and involved in regulating of lipid metabolism and glucose homeostasis.
To evaluate serum betatrophin levels in type 2 obese diabetic women and compare these levels with obese non-diabetic women, and to investigate the relationship between betatrophin levels with fasting blood glucose and lipid profile levels.
The case-control study was included obese women with type 2 diabetic and non-diabetic (n=44 each) of same age and BMI. Serum betatrophin, fasting blood glucose (FBG), total cholesterol, triglycerides and high-density lipoprotein-cholesterol (HDL-C) were measured from all individuals. Low-density lipoprotein-cholesterol (LDL-C) and very-low-density lipoprotein (VLDL-C) were calculated according to the (Friedewald formula).
Serum betatrophin levels were higher (P<0.0001) in type-2 obese diabetic women when compared to obese non-diabetic control, and there was a significant positive correlation (r = 0.332, P = 0.028) between serum betatrophin levels and fasting blood sugar levels. According to Receiver Operating Characteristic curve, betatrophin suitable for distinguishing between type-2 obese diabetic women from obese non-diabetic women (AUC = 0.820, p<0.0001).
Betatrophin hormone showed a highly significant elevated level in type-2 obese diabetic women compare to non-diabetic obese women. The findings of this study established betatrophin a good marker, suitable for distinguishing T2DM women from those without this condition.
Type 2 diabetes, Betatrophin, Obesity
