Transcranial Direct Current Stimulation in Combination with TENS: Effectiveness on Pain and Functional Outcomes in Knee OA Patients-A Study Protocol

The goal of the study is to investigate the effectiveness of combination of Transcranial direct current stimulation (tDCS) and TENS on pain and functional outcomes in patients with knee osteoarthritis. Patients following ACR criteria for knee osteoarthritis, aged more than 45 years will be selected for the study. 80 patients will be selected and will be randomized into following four groups: Active tDCS/active TENS (group 1), Sham tDCS/active TENS (group 2), Active tDCS/sham TENS (group 3), Sham tDCS/sham TENS (group 4). The study will be participant blinded randomized controlled trial. The outcome variables are pain and functional assessment using six minute walk test and self-reported questionnaire KOOS.