1MBChB, DGO, FICGO., Assistant Prof. of Gynecology and Obstetrics, University of Kufa-Collage of Medicine. Iraq
2M.B.CH.B, DGO, AL-Zahraa Maternity and Pediatric, Teaching Hospital, Najaf-Iraq
*Corresponding Author: Dr. Azhar Fadhil Salman Shujairi, M.B.CH.B, DGO, AL-Zahraa Maternity and Pediatric, Teaching Hospital, Najaf-Iraq, Email: azharfssdgo@yahoo.com
Online published on 4 June, 2019.
Misoprostol is a (Prostoglandin) E1 is licensed for use in management of uterine evacuation. This study aimed to compare a vaginal misoprostol loading and non-loading dose regimen for second trimester pregnancy termination. Prospective randomized trial study done included 100 case with singleton nonviable pregnancy at (12–24 weeks) with specific criteria. Using cytotec (mesotac); loading dose misoprostol-tab of 800 μcg, maintenance dose 400 μcg every 6 hrs, non-loading 400 μcg dose both by vaginal route put deep in post Vaginal Fornix. Findings revealed that nausea was significantly higher in loading dose misoprostol-tab of 800 μcg. Approximately half of women in both groups needed analgesia. In Conclusion, in using vaginal misoprostol, better efficacy is achieved within 24 hr in loading and non-loading doses.
Missed abortion, misoprostol (loading, non-loading doses)
