1Ass. Professor, College of Medicine, Almuthana University
2M. B. Ch. B, CABM, Al-Hussein Teaching Hospital, Samawa City
3M.B. Ch. B, FICMS/CABA&IC., Al-Karkh General Hospital
Online published on 4 June, 2019.
Acute injury of the kidney is characterized by a rapid decrease in the speed of glomerular filtration (GF). The development of acute kidney injury (AKI) is associated with a large number of medical complications. Cystatin C can be used as a better biomarker of the glomerular filtration rate than serum creatinine and it can be used for an early diagnosis of any ongoing deterioration in the function of kidneys and monitoring the effectiveness of the recommended treatment.
To assess the serum cystatin C level in ICU patients who developed AKI secondary to major trauma.
A prospective cross sectional study conducted over 190 patients (100 healthy subjects as control group and 90 AKI patients as case group) with different age and gender was included in this study. Blood samples for serum Cys C, SCr, B.urea were collected within the first 24 hrs of onset of injury.
The mean age of the AKI group was (37.3 ± 12.8) years, for control group (34.9 ± 11.5), with high significant association were found between B. urea, S. creatinine, and S. cystatin C. Correlation coefficient between serum Cystatin C-based GFR and serum creatinine-based GFR revealed more negative correlation in Cystatin C-than S. creatinine, this mean that serum Cystatin C-based GFR reflects a decline in GFR with worsening AKI in a much better way than creatinine-based GFR.
Detection of serum cystatin C in early AKI is more precise than serum creatinine detection.
Acute kidney injury, Cystatin C, S. creatinine, Intensive care unit
