A Study of Some biochemical Parameters in blood Serum of Patients with congestive Heart Failure

The goal of this study was to investigate the association between copeptin, chemerin and different biochemical and anthropometric parameters in congestive heart failure (CHF) compared to the healthy control group.

This was a case-controlled, cross-sectional study of eighty-one consecutive patients(48 men, age 64 years, 33 women, age 60years) and 81 age-matched healthy control individuals presented to the Tikrit Teaching Hospital in Tikrit province with a diagnosis of HF between June 2017and January 2018. Demographic and anthropometric variables were estimated. Serum levels of copeptin, chemerin and apelin were measured in fasting blood samples.

There was a significant increase in serum copeptin, and Chemerin, cholesterol, triglycerides, levels whereas decreased in HDL in CHF group when compared with healthy controls. Receiver operator characteristic curve(ROC) curve analysis revealed similar efficacies of copeptin and chemerin levels in their ability to detect unstable plaques with areas under the curve of [(AUC=0.959; 95% CI, 0.890 to 0.990, cutoff value >14.6 pg/mL)], and (AUC=0.917; 95% CI, 0.835 to 0.967, cutoff value >41.76), respectively. Whereas, apelin(AUC=0.785; 95% CI, 0.680 to 0.868, cut of point >0.231).

Future analysis of chemerin copeptin's biological actions, and measurement of copeptin, copeptin levels in the omental depot as well as in the circulation of humans with or without CHF and its co morbidities, will help to define its role in the pathogenesis of these diseases.