Study of Correlation between HbA1c and Renal Dysfunction in Type-2 Diabetes Mellitus

With the rising prevalence of type 2 diabetes it has come to pose a heavy burden on healthcare systems worldwide. Diabetic nephropathy is the most common cause of end-stage renal disease could have a seriously negative impact on the economies of developed as well as developing nations. Diabetic nephropathy can lead to tissue scarring, urine proteins loss and chronic kidney disease, requiring sometimes dialysis or even kidney transplantation. Since the aim of the study is to recognize the importance of measurement of HbA1c in renal dysfunction which might help for the application of appropriate drug regimens and to regulate and monitor glucose levels to improve health conditions in the care of type2 diabetic patients.

blood samples received from either OPD or IPD in plain and EDTA vacutainers was separated from blood to plain vacutainer by centrifugation at 3000rpm for 10 minutes. For HbA1c EDTA vacutainer samples are used. By using different methods serum urea, creatinine estimated on fully automated analyzerEM360

The correlation coefficient as Pearson's correlation coefficient is0.333 between HbA1c and blood urea level with p value <0.0001 which is highly significant and between HbA1c and blood urea level it is-0.026, p value is 0.6484, indicating this negative correlation is significant. Serum creatinine and HbA1c shows positive correlation, p value is 0.4459 showing this correlation is significant. Correlation between HbA1c and serum creatinine in all three age groups is positive.

These findings may provide the basis for the application of appropriate drug regimens and to regulate and monitor glucose levels to improve health conditions in the care of diabetic patients. Since HbA1c is a important measure to assess the micro vascular complications and plasma glucose.