1Post Graduate, Department of Orthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai
2Asst. Director(R&D), Professor, Department of Orthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai
3Asst. Professor, Department of Biomedical Sciences, VIT, Vellore
4Professor and Head, Department of Orthodontics, Sree Balaji Dental College and Hospital, Chennai
5Asst. Professor and Head, Department of General Pathology, VIT, Vellore
6Ph. D Scholar, Department of Biomedical Sciences, VIT, Vellore
*Corresponding Author: Dr. Priya Chatterjee, Post Graduate in Department of Orthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research Chennai-600100, Phone: +91-9840319310, Email: priyachatterjee150@gmail.com
Online published on 11 July, 2019.
Recently Myosin 1H gene has been implicated in mandibular retrognathism. But the quantitative influence of Myosin 1H polymorphism on mandibular retrognathism is yet unexplored. This study was conducted to understand the role of Myosin 1H single nucleotide polymorphisms in mandibular retrognathism using South Indian Dravidian population as samples. Lateral cephalograms were obtained from retrognathic and normal individuals and related to genotype to study the power of association between them. Definite influence of gene make up is seen on muscle growth and in turn mandibular retrognathism but quantitative association could not be determined due to possible over shadowing influence of cybernetics. In future studies considering gene-environment interactions should be investigated to estimate the overall risk of a large sample size to clarify the association of MYO1H gene in causing true mandibular retrognathism.
Mandibular retrognathism, MYO1H gene, Gene Association
