1Department of Child Health, Faculty of Medicine, Wijaya Kusuma University, Surabaya
2Department of Child Health, Faculty of Medicine, Sam Ratulangi University, Manado
3Laboratory of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
Dengue hemorrhagic fever (DHF) is an infectious disease caused by dengue virus and still become a health problem in Indonesia. Interleukin-8 (IL-8) has been widely accepted as a factor correlated with severity of DHF. However, its role in Dengue Haemmorhhagic Shock Syndrome (DHSS) was still poorly understood. This study was conducted to elucidate correlation of IL-8 and DHSS in children.
To determine the correlation between IL-8 and DHF in children.
We conducted across sectional study in pediatric ward general hospital of Prof. Dr. R.D. Kandou Manado in March until August 2011. Fourty children aged 1–13 years old was conducted consecutively and divided in to shock and without shock DHF. IL-8 was examined in each group and the correlation with DHF was analyzed with Spearman rho test using SPSS software withP<0.05.
The mean of IL-8 level in DHF children without shock was 45.63 (95% CI 31.88 to 59.37) ng/ml and in DHF with shock was 411.13 (95% CI 311.46 to 510.80) ng/ml. The correlation between IL-8 and DHF was staticticaly significant (rs = 0, 774, p<0.001).
The IL-8 level in DHF in these two groups were increase, and higher in severe DHF (with shock). Higher level of IL-8 correlated with increasing severity of DHF.
IL-8, DHF, children, interleukin, hemorrhagic fever
