1Department of Medical Microbiology, Koya University, Kurdistan Region, Iraq
2Department of Biology, Faculty of Science and Health, Koya University, Kurdistan Region, Iraq
3Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran
Online published on 11 July, 2019.
Choosing of Syrian mesquite (Prosopis farcta) as potent oral hypoglycemic and anti-oxidant agents for the maintenance of overall health is the purpose of the present study
The inhibitory effect against α-glucosidase and anti-oxidant activities for n-hexan, ethyl acetate and methanol extracts of roots and stalks of Rhubarb (Rhubarb ribes) and roots, a bark of roots, leaves, and fruits of P. farcta have been studied. Different concentrations of extracts were subjected to α-glucosidase inhibitory assay and the percentage of α glucosidase inhibitory activity was calculated. A method of Folin-Ciocalteu was applied to measure the total phenol content, aluminum chloride method with modifications was used to measure total flavonoid content and free radical scavenging activity of the extracts was analyzed using 2, 2-diphenyl-1-picryl-hydrazyl (DPPH) with a finding of the IC50.
The methanol extract of the bark of roots for P. farcta (7.8125 mg/ml) gave the highest percentage (88.52604) of α-glucosidase inhibition out of all extracts. Methanol extract for roots of P. farcta showed the highest content of total flavonoid comparing with all extracts. Ethyl acetate extract for leaves of P. farcta showed stronger ability to scavenge DPPH comparing with all extracts.
Possessing properties of hypoglycemic and antioxidant may qualify P. farcta extracts to use as a potent antioxidant and sugar regulator for the maintenance of overall health.
Prosopis farcta, α-glucosidase, health, hypoglycemic, inhibition
