Indian Journal of Public Health Research & Development

  • Year: 2019
  • Volume: 10
  • Issue: 6

Stress Ulcer Prophylaxis in Patients with Brain Injury: Retrospective Study

1Department of Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Campus B Universitas Airlangga Surabaya Jalan Dharmawangsa Dalam, Surabaya, Indonesia, 60286

*Correspondence Author: Sumarno, Department of Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Campus B Universitas Airlangga Surabaya Jalan, Dharmawangsa Dalam, Surabaya, Indonesia, 60286, Email: sumarnophar1472@gmail.com

Online published on 11 July, 2019.

Abstract

Brain injury is one of the risk factors for stress ulcers. As many as 52% of brain injury patients use inappropriate prophylaxis, this can result in gastrointestinal bleeding and may lead to death. Until now the most widely used type of prophylaxis is the H2-Antagonist receptor, Proton Pump Inhibitor (PPI) and sucralfate.

This study aims to determine the use of stress ulcer prophylaxis in patients with brain injury.

Retrospective study with 43 data of patients with brain injury. The data on stress ulcer prophylaxis during the patient's hospitalization are collected.

There are 3 types of prophylaxis used, namely H2-Antagonists, PPIs, and Sucralfates. The most widely used type is H2-Antagonist, which is 85.7%. The next drugs were PPI by 10.39% and sucralfate by 3.90%. The route of administration is mostly through oral administration of ranitidine as much as 93.5%. Therapy can be given in single drug or in a combination.

The type of drug used for stress ulcer prophylaxis in patients with brain injury is H2-Antagonists, PPIs and Sucralfate. Prophylactic therapy can be given in single drug or in combination. The administration of omeprazole affected the performance of phenytoin and diazepam.

Keywords

Stress ulcer prophylaxis, brain injury, H2-Antagonist, PPI