Indian Journal of Public Health Research & Development
  • Year: 2019
  • Volume: 10
  • Issue: 6

Protein Kinases A (PknA), a Good Target for Vaccine Design against Tuberculosis

1University of Anbar, College of Pharmacy

2University of Anbar, College of Science

*Corresponding Author: Asra'a Adnan Abdul-Jalil University of Anbar, College of Pharmacy, Email: sc.dr_asraa2017@uoanbar.edu.iq

Online published on 11 July, 2019.

Abstract

The tuberculosis (Tb) pandemic continues to rampage despite widespread use of the bacillus Calmette-Guérin vaccine. Novel vaccination strategies are urgently needed to arrest global transmission and prevent the uncontrolled development of multidrug-resistant forms of Mycobacterium tuberculosis.

In this study, protein sequences of Pknb were collected from Genbank database at NCbI, the immunogenic protein was chosen and it's 3D structure retrieved from database to use in the steps of rational vaccine design, High antigenicity value showed in (YIAPEQALGHDASPASDV) and (EFSSDPE) epitopes.

Keywords

Tuberculosis, PknB, Epitopes