1Al-Hilla General Teaching Hospital
2College of Medicine, University of Babylon, Al-Hilla, Iraq
*Corresponding Author: Dr. Haider Abdul Ridha Alkafaji, College of Medicine, University of Babylon, Al-Hilla, Iraq, Email: drhaideralkafaji@gmail.com
Online published on 11 July, 2019.
Urothelial carcinoma of the urinary bladder represents 90% of all primary tumors of this structure. It is one of the most common ten malignancy in Iraq and worldwide. The depth of invasion, particularly for muscularis propria is the most important prognostic and therapeutic determinators. Fascin-1 is an actin bundling protein involved in cell migration and motility and up-regulated in transformed and aggressive epithelial carcinomas like urothelial carcinoma and overexpression is associated with advance stage. The aim of the present study is to evaluate the fascin-1 expression as a predictive marker for assessment of depth of invasion and as prognostic and therapeutic purposes.
Fifty five patients were of age range from 16–95 years with mean age ± SD of 65.8 ± 13.7 years and with different grades and stages were taken from laboratory of histopathology of Al-Hilla Teaching Hospital. Histological sections of paraffin embedded tissue were be taken for H and E staining for assessing grades and stages according to WHO grading system and AJCC staging system, respectively. Immunohistochemical staining by using mouse monoclonal antibody for fascin-1, then correlation between clinicopathological parameters and marker expression were done.
The fascin-1 expression was found not related to age, gender, tumor grade and perineurial invasion(P>0.05). The intense expression was noted predominantly in the invasive component. Tumor size, lympho-vascular invasion and necrosis were noted to be associated with aggressive tumor with increased fascin expression (P<0.05),
fascin-1 can be used as a predictive marker for recurrence and invasion and as a therapeutic target.
Urothelial carcinoma, Fascin-1, Invasion, Tumor grade, Tumor necrosis
