1Department of Biotechnology, College of Biotechnology, Qasim Green University, Iraq
*Corresponding Author: Professor Ali Hassan Altimimi, Department of Biotechnology, College of Biotechnology, Qasim Green University, Iraq, Email: profdralihassanaltimimi@gmail.com
Online published on 11 July, 2019.
Immunohistological (IH) procedure was used to detect the expression of ER, PR and HER2/neu in postoperative paraffin blocks of breast tumors and statistically analyzed their correlations with clinicopathological characteristics. The mean age was 47.3 years (range 31–76 years). Most of the patients (66.0%) were ≤50 years at diagnosis. The left breast was more commonly involved (57%). Tumor size ranged from 0.5–13.0 cm. The staining of Her2/neu was mainly localized in the membrane, whereas ER, PR, were localized in the nucleus. ER positivity was observed in 70% grade I, 48.2% grade II and 3.5% grade III carcinomas (P<0.05). Similarly PR positivity was observed in 70% grade I, 36.14% grade II and 1.75% grade III carcinomas (P<0.05). HER2/neu was positive in 1 (10%) case of grade I carcinoma, 31 (37.35%) cases of the grade II carcinoma and 24 (42.11%) cases of grade III carcinoma. In the HER-2/neu positive tumors, ER and PR expression in high grade tumors was significantly decreased compared with intermediate grade tumors (ER 5.6% vs 10.5; PR 0% vs 5.3%). Among the ER, PR and HER2/neu statuses, a significant correlation was observed between ER expression and PR status (P<0.05).
Breast carcinoma, Estrogen, Progesterone, Her-2/neu receptor, Immunohistology
