1Baghdad University, College of Science, Department of Biotechnology, Iraq
2Mustansiriy University, Iraqi Center for Cancer Medical Genetic Research, Iraq
*Corresponding Author: Ahmed Majeed Al-Shammari Experimental Therapy Department, Iraqi Center for Cancer and Medical Genetic Research, Mustansiriyah University, Baghdad, Iraq Phone: 009647809143825 Email: ahmed.alshammari@iccmgr.org
Online published on 11 July, 2019.
Breast cancer is a significant cause of death affecting females globally. It is the first cause of death from cancer in females in Iraq. AMJ13 Cell line derived from Iraqi female patient was established and used for drug development as in vitro model in cancer research. There are two apoptotic pathways—the extrinsic pathway (activated by ligand engagement of cell surface death receptors) and the intrinsic (mitochondrial) pathway: The biochemical assay for the Her2neu, P53, and bcl-2 receptors have shown the clinical value of knowing the concentration of the receptor within the tissue. The immunocytochemical assay is rapidly taking over from the biochemical assay. This approach should apply to many more biomarkers detected by immunohistochemistry.
Hormone receptor negative, quantitative image analysis, immunocytochemistry
