1Research Scholar, Department of Chemistry & Biochemistry, SRM University, Delhi, NCR, Haryana
2Associate Professor, Department of Chemistry & Biochemistry, SRM University, Delhi, NCR, Haryana
3Assistant Professor, Department of Clinical Biochemistry, VP Chest Institute, University of Delhi, Delhi
4Consultant Chest Specialist & HOD (Chest&TB), Rajan Babu Institute for Pulmonary Medicine & Tuberculosis, Delhi, India
5Department of Clinical Biochemistry VP Chest Institute, University of Delhi, Delhi
Online published on 19 August, 2019.
Tumour Necrosis Factor (TNF-α) is one of the most commonly studied cytokine of TNF superfamily. Patho-physiologically generation of high levels of TNF-α is a development of inflammatory responses for many of the chronic diseases. Simultaneously in pulmonary diseases increased level of TNF-α in blood serum relates with the cytotoxicity. The Study was conducted on 100 patients of Rajan Babu Institute for Pulmonary Medicine & Tuberculosis (RJPIMT) Hospital. Patient diagnosis was confirmed via Spirometry. The result reveals that the serum TNF-α level increases with the COPD severity. The mean values of TNF were significantly increased with the decreased FEV/FVC. The present study showed that serum TNF-α level correlates with severity of airway obstruction in Spirometry among the COPD patients. It is worth mentioning that serum TNF-α level may plays an important role to diagnose chronic obstructive pulmonary disease as a useful marker to monitor the disease severity in addition to spirometric parameters like FVC, FEV1 and FEV1/FVC ratio.
TNF-α, COPD, Exacerbations, Spirometry
