Indian Journal of Public Health Research & Development

Hypothyroidism is strongly related to increased risk of cardiovascular diseases due to its potential association with atherogenic lipid profile. Hypothyroidism also can even cause premature atherosclerosis. Untreated hypothyroidism is the most common cause of reversible hyperlipidemia.

Blood samples received from either OPD or IPD in plain and EDTA vacutainer was separated from blood to plain vacutainer by centrifugation at 3000rpm for 10 minutes. For HbA1c EDTA vacutainer samples are used. By using different methods serum urea, creatinine estimated on fully automated analyzer EM360.

Age wise distribution show a more number in <50years group, indicating early occurrence of hypothyroidism, might be because of more stressed lifestyle resulting in deranged thyroid metabolism. Our study shows in gender wise distribution more number for female subjects, since hypothyroidism is more common in females. Regarding VLDL levels, significant correlation was found with T4, indicating changing impact on triglycerides metabolism with severity of hypothyroidism. Since our objective of the study is to establish a correlation between lipid profile and TSH as our finding show negative correlation TSH and total cholesterol and LDL cholesterol.

Since our objective of the study is to establish a correlation between lipid profile and TSH as our finding show negative correlation TSH and total cholesterol and LDL cholesterol. But this need more research work on this aspect of independent correlation of TSH and total cholesterol. This can further help to diagnose early hypothyroidism with only two parameters TSH and total cholesterol, if proved and thoroughly researched.